reticulum possesses an ATP-driven calcium pumping
mechanism, which accumulates calcium within its
membrane system and thus reduces the cytoplasmic
concentration of calcium around the myofilaments.
2. Actin-myosin inhibition. At low calcium
concentrations, TnC is unoccupied and tropomyosin
repositions itself so that it sterically blocks the
myosin-binding site on each actin molecule.
1. Calcium uptake. The sarcoplasmic
reticulum possesses an ATP-driven calcium pumping
mechanism, which accumulates calcium within its
membrane system and thus reduces the cytoplasmic
concentration of calcium around the myofilaments.
2. Actin-myosin inhibition. At low calcium
concentrations, TnC is unoccupied and tropomyosin
repositions itself so that it sterically blocks the
myosin-binding site on each actin molecule.
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