23 Şubat 2014 Pazar

Chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is characterised by airflow obstruction that is not fully reversible. The airflow limitation is usually progressive and is associated with an abnormal inflammatory response of the lungs to noxious particles or gases.[1]The airflow obstruction is due to a combination of airway and parenchymal damage. COPD is now the preferred term for patients with airflow obstruction who were previously diagnosed as having chronic bronchitis or emphysema.[2]

Airflow obstruction is defined as a reduced post-bronchodilator FEV1/FVC ratio (where FEV1 is forced expiratory volume in 1 second and FVC is forced vital capacity), such that FEV1/FVC is less than 0.7. If FEV1 is 80% or more of predicted normal, a diagnosis of COPD should only be made in the presence of respiratory symptoms - eg, breathlessness or cough.[2]

The respiratory drive is normally largely initiated by PaCO2 but in COPD hypoxia can be a strong driving force, which can therefore be reduced if the hypoxia is corrected.

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