Definite (All studies show statistical
significance)
Ø Genetic predisposition to
atopy
Ø Genetic predisposition to
hyper responsiveness
Ø Family history of
Asthma/Atopy
Ø Early lung disease /
Bronchiolitis
Ø Increased IgE
Ø Positive skin test(RAST)
Ø Maternal smoking
Ø Concurrent Allergic
Rhinitis/Atopic Dermatitis (Early onset < 01 yr)
Ø House dust / Mite
Ø Male
Probable (Multiple studies are in favour,
occasional not)
Ø Immediate / Early food
reactivity
Ø Increased humidity / House
dampness
Ø Pets at home (Furred
animals)
Ø Eosinophilia (Adult >
children)
Ø LBW
Ø Black race
Ø Obesity
Possible (Equal studies are in favour / against)
Ø Air pollution
Ø Skin test reactive to Milk
/ Eggs /peanuts < 01 yr
Ø Not breastfed
Ø Paternal smoking
Ø Cockroach allergy
Ø Childhood Obesity
Ø Day care attendance
Ø Central city residence
Ø Low Socioeconomic status
Ø Cooking wood / charcoal
Ø Increased IgE levels
Ø Maternal young age
Unlikely (Most studies show statistically no
significance)
Ø H/O Urticaria
Ø Delayed food reaction
Ø LRTI after infancy
No Association
Ø IgG, IgA levels
Ø Gas stove at home
Ø Proportions of proteins /
fish in diet
Triggers
Ø Allergens – indoor : Domestic furred pets, mites, cockroach,
Ø Allergens – outdoor:
Pollen, fungi, molds, yeasts
Ø Viral infection / RSV
Ø Smoking – active &
passive
Ø Occupational sensitizers
Ø Exercise
Ø Weather change
Ø Emotional
Ø Role of food / diet – Proteins
/ additives
Ø Endocrine – e.g. Puberty
